[1]朱心红,杨建明,高天明.脑心通对大鼠脑缺血海马CA1区神经元损伤的保护作用[J].南方医科大学学报,2004,(10):1123-1125.
 ZHU Xin-hong,YANG Jian-ming,GAO Tian-ming.Neuroprotective effects of Naoxintong against neuronal injury in hippocampal CA1 region following transient forebrain ischemia in rats[J].Journal of Southern Medical University,2004,(10):1123-1125.
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脑心通对大鼠脑缺血海马CA1区神经元损伤的保护作用()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2004年10期
页码:
1123-1125
栏目:
出版日期:
2004-10-01

文章信息/Info

Title:
Neuroprotective effects of Naoxintong against neuronal injury in hippocampal CA1 region following transient forebrain ischemia in rats
作者:
朱心红1 杨建明1 高天明12
1. 南方医科大学生理学教研室, 广东, 广州, 510515;
2. 南方医科大学解剖学教研室, 广东, 广州, 510515
Author(s):
ZHU Xin-hong1 YANG Jian-ming1 GAO Tian-ming12
关键词:
脑心通中风回春丸尼莫地平海马脑缺血神经元/病理学
Keywords:
NaoxintongZhongfenghuichunwannimodipinehippocampuscerebral ischemianeurons/pathology
分类号:
R287;R74.1
摘要:
目的 研究脑心通、中风回春丸对大鼠前脑缺血海马CA1区神经元损伤的保护作用。方法 采用改良的Pulsinelli四血管闭塞法制作前脑缺血模型,光镜下观察并计CA1区存活锥体细胞密度;并与尼莫地平对照。结果 脑心通及尼莫地平灌胃给药组大鼠海马CA1区存活锥体细胞密度明显高于生理盐水组(P<0.05,P<0.001),但脑心通与尼莫地平组之间无明显差异;中风回春丸无明显的神经保护作用。结论 脑心通具有明显的神经保护作用。
Abstract:
Objective To examine the neuroprotective effects of Naoxintong and Zhongfenghuichunwan on neuronal injury in CA1 region of rat hippocampus following transient forebrain ischemia.Methods Transient rat forebrain ischemia for 15 min was induced by modified four-vessel occlusion method. The density of survived pyramidal cells (neurons per 1 mm linear length) in CA1 region of the hippocampus was measured under light microscope. Results In Naoxintong or nimodipine-treated rats,the density of survived pyramidal cells in CA1 region was significantly greater than that of saline group (P<0.05,P<0.001,respectively),but oral administration of Zhongfenghuichunwan had no obvious effect on ischemia-induced neuronal damage in CA1 region.Conclusion Naoxintong can protect CA1 neurons against ischemic insult in rats.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2004-4-10。
基金项目:国家自然科学基金(30125013; 30330240; 30371772);广东省自然科学基金(37047);教育部“长江学者”奖励计划
作者简介:朱心红(1968- ),男,中西医结合临床专业硕士、神经生物学专业博士,主要从事缺血性脑损伤的修复及机制研究
通讯作者:高天明(1960-),解剖学教研室教育部"长江学者"特聘教授,博士生导师,电话:020-61648216
更新日期/Last Update: 1900-01-01