[1]黄仲曦,姚开泰.用文献轮廓挖掘鼻咽癌微阵列表达数据[J].南方医科大学学报,2004,(07):798-801.
 HUANG Zhong-xi,YAO Kai-tai.Mining gene expression microarray data of nasopharyngeal carcinoma by literature profiling[J].Journal of Southern Medical University,2004,(07):798-801.
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用文献轮廓挖掘鼻咽癌微阵列表达数据()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2004年07期
页码:
798-801
栏目:
出版日期:
2004-07-01

文章信息/Info

Title:
Mining gene expression microarray data of nasopharyngeal carcinoma by literature profiling
作者:
黄仲曦 姚开泰
第一军医大学病理教研室肿瘤研究所, 广东, 广州, 510515
Author(s):
HUANG Zhong-xi YAO Kai-tai
Institute of Cancer Research, Department of Pathology, First Military Medical University, Guangzhou 510515, China
关键词:
鼻咽癌信号通路微阵列数据挖掘生物信息学
Keywords:
nasopharyngeal carcinomasignalmicroarraydata-miningbioinformation
分类号:
R36
摘要:
目的 探索鼻咽癌异常信号通路。方法 根据鼻咽癌微阵列表达谱,采用基于文献轮廓的数据挖掘方法,从Medline文献数据库中提取与基因相关的文献并分析词的频率,再根据重复发生和共发生的过滤标准提取功能相关的词,最后根据词的发生频率对基因进行功能聚类。结果 基因表达谱的112个差异表达基因聚成16组功能类别:4组暗示EBV感染、6组显示鼻咽癌变过程、2组参与能量代谢、1组提示蛋白的异常磷酸化、2组与其它疾病相关、1组与肌肉组织活性相关。肿瘤发生发展过程中常见的P53和Rb信号通路的异常在本研究中则未发现。结论 鼻咽癌的发生发展可能由特殊的信号通路引起。
Abstract:
Objective To study abnormal signal pathway in nasopharyngeal carcinoma (NPC). Method NPC gene expression microarray data was mined by analysis of literature profiles generated by extracting the frequencies of certain terms from the abstracts stored in the Medline literature database. The terms were then filtered on the basis of both repetitive occurrence and co-occurrence among multiple gene entries. Finally, clustering analysis was performed on the retained frequency values, shaping a coherent picture of the functional relationship among large and heterogeneous lists of genes. Result Sixteen function groups were found among 112 abnormally expressed genes, including 4 groups indicative of Epstein-Barr virus (EBV) infection, 6 groups indicative of normal nasopharyngeal tissues that acquired essential capabilities to develop into tumor, 2 groups involved in energy metabolism, 1 group suggesting abnormal phosphorylation of proteins, 2 groups related tother diseases, and 1 group associated with muscle activities. The pathways of p53 and Rb, which were frequently abnormal during tumor progression, were not found in these groups. Conclusion Initiation and progression of NPC may be caused by special signal transduction pathways.

参考文献/References:

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[11] 黄仲曦,孙青,姚开泰,等.用文献轮廓挖掘大肠癌转移芯片表达谱[J].第一军医大学学报,2003,11:1195-7.Huang ZX, Sun Q, Yao KT, et al. Mining microarray gene expression data of metastatic colorectal cancer by literature profiling[J]. J First Mil Med Univ/Di Yi Jun Yi Da Xue Xue Bao, 2003, 11: 1195-7.
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备注/Memo

备注/Memo:
收稿日期:2003-9-29。
基金项目:广东省“十五”专项基金(A1080201)
作者简介:黄仲曦(1974- ),男,第一军医大学在读博士研究生,讲师,电话:020-61640114-89099,E-mail:zxhuang@fimmu.com
更新日期/Last Update: 1900-01-01