[1]杨小兵,蒋建平,张训.肝病变程度和维生素K1对慢性肾功能衰竭病人肝活检术后出血的影响[J].南方医科大学学报,2004,(07):787-788.
　YANG Xiao-bing,JIANG Jian-ping,ZHANG Xun.Influence of liver lesions and vitamin K1 on bleeding after liver biopsy in patients with chronic renal failure[J].Journal of Southern Medical University,2004,(07):787-788.
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肝病变程度和维生素K1对慢性肾功能衰竭病人肝活检术后出血的影响()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2004年07期
页码:
787-788
栏目:
出版日期:
2004-07-01

文章信息/Info

Title:
Influence of liver lesions and vitamin K1 on bleeding after liver biopsy in patients with chronic renal failure
作者:
杨小兵;  蒋建平;  张训
第一军医大学南方医院肾内科, 广东, 广州, 510515
Author(s):
YANG Xiao-bing;  JIANG Jian-ping;  ZHANG Xun
Department of Nephrology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
关键词:
乙型肝炎病毒; 丙型肝炎病毒; 出血; 肝/组织学; 维生素K1
Keywords:
hepatitis B virus; hepatitis C virus; hemorrhage; liver/histology; vitamin K1
分类号:
R512.6;R586
摘要:
目的 探讨肝脏病变程度及维生素K1对慢性肾功能衰竭病人肝活检术后出血的影响。方法 选择92例合并慢性乙型肝炎病毒和丙型肝炎病毒感染的肾移植术前血液透析患者接受肝穿刺活检,以半定量积分法评价肝组织炎症和纤维化程度,其中34例肝活检术前使用维生素K1 10mg肌肉注射,2次/d,连续3 d。结果 92例患者肝活检术后出血11例(12.0%)。其中34例术前使用维生素K1者出血4例、58例未使用维生素K1者出血7例,两者无显著差异(P>0.05);术后出血与肝脏病理分级、分期之间无差别(P>0.05)。结论 慢性肾功能衰竭患者肝穿刺后出血的发生率较高,穿刺前使用维生素K1并不能明显降低术后出血发生率,术后出血与肝脏病变程度无明显相关关系。
Abstract:
Objective To investigate the influence of liver lesions and vitamin K1 on bleeding after liver biopsy in patients with chronic renal failure and hepatitis virus infection. Methods Ninety-two renal transplant recipients on hemodialysis with hepatitis B or C virus infection received percutaneous liver biopsy. The severities of liver inflammation and fibrosis were evaluated by semi-quantitative technique. Thirty-four patients were given intramuscular injection of vitamin K1 before liver biopsy at the dose of 10 mg twice daily for 3 d ays. Results The total incidence of bleeding after liver biopsy was 12.0% (11/92) in these patients, and the use of vitamin K1 did not significantly influence the incidence of bleeding, nor did the degree of liver lesions. Conclusions Bleeding occurred with a relatively high incidence after liver biopsy in patients with chronic renal failure and hepatitis virus B or C infection; vitamin K1 before liver biopsy could not reduce the incidence of bleeding, which is not correlated with the degree of liver lesions.

参考文献/References:

[1] 中华医学会传染病和寄生虫病学会、肝脏学会.病毒性肝炎防治方案[J].中华内科学杂志(Chin J Inter Med),2001,40(1):62-8.
[2] 彭文伟.传染病学[M].第四版.北京:人民卫生出版社,1998.17-8.
[3] Ozdogan M, Ozgur O, Boyacioglu S, et al. Percutaneous liver biopsy complications in patients with chronic renal failure[J]. Nephron, 1996,74(2): 442-3.
[4] McGill DB, Rakela J, Zinsmeister AR, et al. A 21-year experience with major haemorrhage after percutanous liver biopsy [J]. Gastroenterology, 1990, 99(5): 1396-400.

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备注/Memo

备注/Memo:
收稿日期:2004-1-10。
基金项目:广东省医学科研基金(A2003436)
作者简介:杨小兵(1978- ),男,2003年毕业于第一军医大学,硕士,医师,电话:020-61641595,E-mail:yxb7829@hotmail.com
更新日期/Last Update: 1900-01-01