[1]商健彪,李彦豪,刘方颖,等.肝细胞性肝癌18F-FDG PET显像与血清甲胎蛋白的相关性研究[J].南方医科大学学报,2004,(06):697-699.
 SHANG Jian-biao,LI Yan-hao,LIU Fang-ying,et al.18 F-fluorodeoxyglucose uptake in hepatocellular carcinoma on positron emission tomography correlates with α-fetoprotein[J].Journal of Southern Medical University,2004,(06):697-699.
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肝细胞性肝癌18F-FDG PET显像与血清甲胎蛋白的相关性研究()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2004年06期
页码:
697-699
栏目:
出版日期:
2004-06-01

文章信息/Info

Title:
18 F-fluorodeoxyglucose uptake in hepatocellular carcinoma on positron emission tomography correlates with α-fetoprotein
作者:
商健彪1 李彦豪1 刘方颖2 曾庆乐1 王江云1 何晓峰1 陈勇1
1. 第一军医大学南方医院介入治疗科, 广东, 广州, 510515;
2. 第一军医大学南方医院影像中心, 广东, 广州, 510515
Author(s):
SHANG Jian-biao1 LI Yan-hao1 LIU Fang-ying2 ZENG Qing-le1 WANG Jiang-yun1 HE Xiao-feng1 CHEN Yong1
1. Department of Interventional Radiology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China;
2. Diagnostic Imaging Center, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
关键词:
肝细胞性肝癌脱氧葡萄糖体层摄影发射型计算机甲胎蛋白
Keywords:
hepatocellular carcinomadexyglucosetomographyemission computedalpha-fetoprotein
分类号:
R735.705;R817.8
摘要:
目的 探讨肝细胞性肝癌(HCC)的葡萄糖代谢与血清甲胎蛋白(AFP)之间的关系。方法 45例经组织病理学检查证实的HCC患者行全身18F-FDG PET显像。测定肿瘤病灶的葡萄糖标准摄取值(SUV)、肿瘤与非肿瘤区SUV比值,分析二者同AFP之间的关系。结果 45例HCC患者中,43例肝内原发病灶及转移的淋巴结其PET显像表现为异常放射性浓聚灶,2例高分化HCC显像结果阴性。线性结果分析表明,AFP同SUV、SUV比值之间存在一定的相关性,r值分别为0.426(P<0.05)和0.532(P<0.001)。结论 HCC 18F-FDG PET显像测得的SUV及SUV比值同血清AFP之间存在显著的相关关系,表明AFP同肿瘤细胞的增殖及代谢有相关性。
Abstract:
Objective To investigate whether 18F-fluorodexyglucose (FDG) uptake in the primary hepatocellular carcinoma (HCC) correlates with serum α-fetoprotein (AFP). Methods Forty-five patients with histologically confirmed HCC underwent whole-body 18F-FDG PET examination. Standardized uptake value (SUV) and tumor-to-nontumor ratio of the SUV (SUVratio) were calculated, and the relationship between serum AFP and glucose metabolism in HCC was analyzed. Results Of the 45 cases, the primary tumor and metastatic lymph nodes were clearly displayed on PET images in 43 cases and the well-differentiated tumors were shown negative in the other 2 cases. A linear correlation of the AFP with SUV (r=0.426, P<0.05) and SUVratio (r=0.532, P<0.001) was noted. Conclusion Serum AFP correlates significantly with both SUV and SUN ratio, indicating that AFP is involved in glucose metabolism and cell proliferation in HCC.

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备注/Memo

备注/Memo:
收稿日期:2003-12-28。
作者简介:商健彪(1968- ),男,第一军医大学在读博士研究生,电话:020-61642084.
更新日期/Last Update: 1900-01-01