[1]于立新,王志鹏,付绍杰,等.丙型肝炎病毒感染对肾移植术后影响的临床研究[J].南方医科大学学报,2004,(06):682-684.
 YU Li-xin,WANG Zhi-peng,FU Shao-jie,et al.Hepatitis C virus infection and clinical outcome of kidney transplantation[J].,2004,(06):682-684.
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丙型肝炎病毒感染对肾移植术后影响的临床研究()
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《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2004年06期
页码:
682-684
栏目:
出版日期:
2004-06-01

文章信息/Info

Title:
Hepatitis C virus infection and clinical outcome of kidney transplantation
作者:
于立新 王志鹏 付绍杰 王亦斌 杜传福 徐健 邓文锋
第一军医大学南方医院肾移植科, 广东, 广州, 510515
Author(s):
YU Li-xin WANG Zhi-peng FU Shao-jie WANG Yi-bin DU Chu-fu XU Jian DENG Wen-feng
Department of Kidney Transplantation, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
关键词:
丙型肝炎病毒丙型肝炎肾移植移植物存活存活率
Keywords:
hepatitis C virushepatitis C virus infectionrenal transplantationgraft survivalsurvival rate
分类号:
R512.63;R699.2
摘要:
目的 探讨丙型肝炎病毒(Hepatitis C virus,HCV)感染对肾移植术后的影响。方法 比较86名HCV感染和86名非HCV感染病人肾移植术后1,3,5年人/肾存活率和急、慢性排斥反应的发生率,并对死亡病例的原因进行分析。结果 两组病人在肾移植术后不同时间人/肾的存活率分别为:术后1年(94.2%/90.7%和96.8%/96.0%);术后3年(88.4%/79.1%和90.7%/87.2%);术后5年(74.4%/73.3%和87.2%/81.4%)。两组急性排斥反应发生率为31.3%和21.2%,慢性排斥反应发生率为12.5%和6.5%。其中HCV感染组5年人存活率低于非HCV感染组(P<0.05),而其他各项结果无统计学差异(P>0.05)。肝病为感染组的首位死亡原因(36.4%)。结论 HCV感染对肾移植受者术后长期存活存在负面影响,HCV感染应作为肾移植手术的相对禁忌证。
Abstract:
Objective To study the influence of hepatitis C virus (HCV) infection on the clinical outcome of kidney transplan-tation. Methods The recipient/graft survival, the incidence of acute/chronic rejection and cause of death in 86 HCV-infected recipients of renal transplantation were compared with those in another 86 recipients without HCV infection. Results HCV-infected recipients had significantly shorter 5-year survival (74.4%) than those without HCV infection (87.2%, P<0.01). The 1-year (94.2%/90.7% vs 96.8%/96.0%) and 3-year recipient/graft survival rates (88.4%/79.1% vs 90.7%/87.2%), the incidence of acute/chronic rejection (31.3% vs 21.2%, and 12.5% vs 6.5%) and the 5-year graft survival (73.3%/81.4%) were comparable between the two groups (P>0.05). Hepatic disease was identified as the primary cause of mortality. Conclusions HCV infection may affect the long-term survival of the recipients with kidney transplantation, and therefore should be considered as a relative contraindication of kidney transplantation.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2004-1-6。
作者简介:于立新(1950- ),男,第一军医大学南方医院肾移植科主任,教授、主任医师,电话:020-61641720,E-mail:liuxy@fimmu.com.
更新日期/Last Update: 1900-01-01