[1]刘俊,刘志强,陶惠琴.血液净化对慢性肾功能衰竭患者全段甲状旁腺激素的影响[J].南方医科大学学报,2004,(02):234-235.
 LIU Jun,LIU Zhi-qiang,TAO Hui-qin.Effect of blood purification on plasma levels of intact parathyroid hormone in patients with chronic renal failure[J].,2004,(02):234-235.
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血液净化对慢性肾功能衰竭患者全段甲状旁腺激素的影响()
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《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2004年02期
页码:
234-235
栏目:
出版日期:
2004-02-01

文章信息/Info

Title:
Effect of blood purification on plasma levels of intact parathyroid hormone in patients with chronic renal failure
作者:
刘俊 刘志强 陶惠琴
第一军医大学南方医院肾内科, 广东, 广州, 510515
Author(s):
LIU Jun LIU Zhi-qiang TAO Hui-qin
Department of Nephrology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
关键词:
甲状旁腺激素血液灌流血液透析肾功能衰竭慢性
Keywords:
parathyroid hormonehemoperfusionhemodialysiskidney failure chronic
分类号:
R692.5
摘要:
目的 研究血液灌流和/或血液透析对慢性肾功能衰竭(CRF)患者全段甲状旁腺激素(iPTH)的影响。方法 用放射免疫测定法检测40例规律血液透析患者治疗前后iPTH水平。结果 血液灌流和/或血液透析后iPTH水平均降低,但血液灌流组降低幅度大于血液透析组(P=0.031)。结论 血液灌流加血液透析能比单纯血液透析更有效地降低CRF患者iPTH水平。
Abstract:
Objective To study the effects of hemoperfusion and/or hemodialysis on plasma levels of intact parathyroid hormone (iPTH) in patients with chronic renal failure (CRF). Methods A total of 40 uremic patients were randomly divided into two groups to receive hemoperfusion in combination with hemodialysis (HP+HD) or exclusive hemodialysis (HD), respectively. Plasma iPTH concentration was measured by means of radio immunoassay. Results After the blood purification procedures, the patients’ plasma iPTH levels were reduced from 1 508.70±1 268.89 to 1 049.04±992.91 μg/ml (P<0.001) in HD group and from 1 600.70±1 151.15 to 745.47±785.02 μg/ml (P<0.001) in HP+HD group. Conclusion Blood purification with hemoperfusion plus hemodialysis may decrease plasma iPTH levels more efficiently than hemodialysis performed alone.

参考文献/References:

[1] 徐启河,黄颖,刘平,等.三种甲状旁腺激素测定在血液透析患者的意义[J].北京医科大学学报(J BeijingMed Univ),1994,26(4):287-90.
[2] Hellman P, Balkman U, Damielson BG, et al. Values of intact serum parathyroid hormone in different stages of renal insufficiency[J].Scand J Urol Nephrol, 1991, 25(3): 227-32.
[3] Felsenfeld AJ, Llach F. Parathyroid gland function in chronic renal failure[J]. Kidney Int, 1993, 43(4): 771-89.
[4] Rodriguez M, Martin-Malo A, Martinez ME, et al. Calcemic response to parathyroid hormone in renal failure: role ofcalcitriol and the effect ofparathyroidectomy[J]. Kidney Int, 1991,40(6): 1055-62.
[5] Fukagawa M, Kaname S, Igarashi T, et al. Regulation of parathyroid hormone synthesis in chronic renal failure in rats[J]. Kidney Int,1991, 39(5): 874-81.
[6] Perez-Mijares R, Gomez-Fernandez P, Almararz-Jimenez M, et al.Treatment of severe secondary hyperparathyroidism with administration of calcium carbonate intermittent high oral doses of 1, 25(OH)2D3 and dialysate with 3 mEq/L calcium concentration[J]. Am J Nephrol,1993, 13(2): 149-54.

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备注/Memo

备注/Memo:
收稿日期:2003-5-11。
作者简介:刘俊(1962-),男,山东龙口人,1985年毕业于第一军医大学,硕士,副教授,副主任医师,电话:020-61641598
更新日期/Last Update: 1900-01-01