[1]陈永,邱富娟,朱兴旺,等.血管翳并非类风湿关节炎的专利—膝骨关节炎血管翳病理形态观察[J].南方医科大学学报,2019,(06):747.[doi:10.12122/j.issn.1673-4254.2019.06.19]
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血管翳并非类风湿关节炎的专利—膝骨关节炎血管翳病理形态观察()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2019年06期
页码:
747
栏目:
出版日期:
2019-06-16

文章信息/Info

Title:
Pannus does not occur only in rheumatoid arthritis: a pathological observation of pannus of knee osteoarthritis
作者:
陈永邱富娟朱兴旺莫海月吴自勍肖长虹
关键词:
血管翳骨关节炎类风湿关节炎组织病理学
Keywords:
pannus osteoarthritis rheumatoid arthritis histopathology
DOI:
10.12122/j.issn.1673-4254.2019.06.19
摘要:
目的比较类风湿关节炎(RA)与骨关节炎(OA)滑膜组织病理学差异。方法回顾性分析72例RA、24例OA患者经关节 腔镜手术获得的滑膜标本病理苏木精-伊红(HE)染色切片,经两位高年资病理医师对滑膜细胞(FLS)增生程度、血管增生程度、 纤维组织增生程度、淋巴细胞浸润程度几个方面进行量化评分,对有无浆细胞浸润采用计数统计。并结合临床分析RA、OA滑 膜病理形态学的差异。结果OA滑膜也存在着血管翳形成,但OA-FLS增生程度、纤维组织增生程度和淋巴细胞浸润程度,及 浆细胞浸润比例明显低于RA血管翳;血管增生程度低于RA血管翳,但无统计学差异。OA血管翳在显微镜下可表现的与RA 难以区分。结论OA滑膜存在着血管翳病理变化,FLS增生程度、纤维组织增生程度和淋巴细胞浸润程度,及浆细胞浸润比例 明显低于RA血管翳;OA与RA血管翳的差异给诊断和治疗提示了一定潜在的价值。
Abstract:
Objective To compare the histopathological features of the synovium between rheumatoid arthritis (RA) and osteoarthritis (OA). Methods We retrospectively analyzed the synovial specimens obtained after synovial surgery in 72 cases of RA and 24 cases of OA. Two independent pathologists reviewed the sections of the synovial tissues with HE staining, quantitatively scored the degree of fibroblast-like synoviocyte (FLS) hyperplasia, vascular hyperplasia, fibroplasia, and lymphocyte infiltration, and examined the presence plasma cell infiltration. The pathological morphology of the synovial tissues was evaluated in relation with the clinical data of the patients. Results Pannus formation was also detected in the synovium of OA patients, which showed a lesser degree of OA-FLS hyperplasia, fibrosis and lymphocyte infiltration and a significantly lower rate of plasma cell infiltration compared with the pannus in RA patients. Vascular proliferation was also milder in the pannus of OA patients than in RA pannus, but the difference was not statistically significant. In OA patients, the pannus could be observed under a microscope and was difficult to distinguish from that in RA patients. Conclusion Pannus formation occurs also in the synovium of OA patients but with milder FLS hyperplasia, fibrosis and lymphocyte infiltration and a lower rate of plasma cell infiltration compared with the pannus in RA patients. These differences in the pannus between OAand RA can be of potential value in the diagnosis and treatment of the patients.

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更新日期/Last Update: 1900-01-01