[1]郑倩雯,李亚文,张露,等.饮酒与缺血性脑卒中幸存者死亡的关联性[J].南方医科大学学报,2019,(04):422.[doi:10.12122/j.issn.1673-4254.2019.04.07]
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饮酒与缺血性脑卒中幸存者死亡的关联性()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2019年04期
页码:
422
栏目:
出版日期:
2019-04-26

文章信息/Info

Title:
Association between drinking and all-cause mortality in patients with ischemic stroke
作者:
郑倩雯李亚文张露姚强张敬李宓儿王菊朱彩蓉
关键词:
缺血性脑卒中饮酒全死因死亡
Keywords:
ischemic stroke drinking all-cause death
DOI:
10.12122/j.issn.1673-4254.2019.04.07
摘要:
目的探讨饮酒与缺血性脑卒中幸存者全死因死亡的关系。方法连续入组2010年1月~2018年7月入住四川大学华西医 院的首发缺血性脑卒中幸存者,每3个月随访1次,采用卡方检验比较卒中前饮酒者与不饮酒者基线特征的差异,通过构建cox 比例风险回归模型,分析卒中前是否饮酒、饮酒年限、饮酒频率、平均每次酒精摄入量及随访期间是否饮酒与幸存者死亡的关联 性。结果本研究最终纳入855例缺血性脑卒中幸存者进行分析,其中死亡140例。卡方检验显示卒中前饮酒者与不饮酒者在 性别(P<0.001)、每周体育锻炼时间(P=0.035)、是否吸烟(P<0.001)和是否有心脏疾病(P<0.001)方面的差异有统计学意义。多 因素Cox回归分析结果提示:随访期间饮酒者(P=0.001)、卒中前饮酒年限小于28年者(P=0.035)以及每月饮酒5~20次的男性 和4~9次的女性(P=0.030)死亡风险更低。尚未发现卒中前是否饮酒、平均每次酒精摄入量与缺血性脑卒中幸存者死亡有关。 结论卒中前饮酒的年限和频率、随访期间是否饮酒与缺血性脑卒中幸存者全死因死亡有关,建议今后研究者纳入随访期间饮 酒行为的具体特征变量,进一步探究饮酒与卒中幸存者死亡的关系。
Abstract:
Objective To investigate the association between alcohol drinking and all-cause death in patients with ischemic stroke. Methods Between January, 2010 and July, 2018, consecutive patients with first-episode ischemic stroke admitted in the West China Hospital, Sichuan University were enrolled, and all the patients were followed up every 3 months. Chi-square test was used to compare the differences in the baseline characteristics between the pre-stroke drinkers and the nondrinkers. The Cox regression model was used to analyze the effects of drinking status, drinking years, drinking frequency, average single alcohol intake before stroke and drinking status during the follow-up period on the mortality of patients after discharge. Results A total of 855 patients with ischemic stroke were enrolled, and deaths occurred in 140 of these patients. Chi-square test showed significant differences in gender (P<0.001), weekly physical exercise time (P=0.035), smoking (P<0.001), and heart disease (P<0.001) between the pre-stroke drinkers and nondrinkers. Multivariate Cox regression analysis showed that drinking during the follow-up period (P=0.001), drinking for less than 28 years before stroke (P=0.035) and a moderate drinking frequency (5 to 20 times per month for males and 4 to 9 times per month for females; P=0.030) were associated with a lowered risk of death after discharge. No significant effects of pre-stroke drinking status or average single alcohol intake were found on death after ischemic stroke. Conclusions The drinking years and drinking frequency before stroke and drinking status during the follow-up period are related to the all-cause mortality in patients with ischemic stroke. Investigations of the more specific variables of drinking behaviors during the follow-up period are needed to further clarify the association between drinking and death after ischemic stroke.
更新日期/Last Update: 1900-01-01