[1]李政,胡蕴,马建华.晚餐后不同时段运动对2型糖尿病患者餐后血糖谱的影响[J].南方医科大学学报,2018,(10):1165.[doi:10.12122/j.issn.1673-4254.2018.10.03]
点击复制

晚餐后不同时段运动对2型糖尿病患者餐后血糖谱的影响()
分享到:

《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2018年10期
页码:
1165
栏目:
出版日期:
2018-10-16

文章信息/Info

Title:
Effect of moderate exercise for 30 min at 30 min versus 60 min after dinner on glycemic control in patients with type 2 diabetes: a randomized, crossover, self-controlled study
作者:
李政胡蕴马建华
关键词:
2型糖尿病运动动态血糖监测餐后高血糖
Keywords:
diabetes mellitus type 2 exercise hyperglycemia postprandial period
DOI:
10.12122/j.issn.1673-4254.2018.10.03
摘要:
目的使用动态血糖监测(CGM)观察晚餐后0.5 h与晚餐后1 h短时中强度运动分别对2型糖尿病(T2DM)患者血糖谱的 影响。方法纳入15例平时缺乏运动的无严重并发症T2DM患者(9名男性,6名女性),且均未使用胰岛素。将受试者随机分配 到晚餐后0.5 h运动组和晚餐后1 h运动组,进行0.5 h中强度运动,1周后交叉。运动强度设定为40%储备心律(HRR)。在饮食 标准化和药物治疗不变的条件下,通过CGM监测血糖。观察受试者晚餐后2 h平均血糖、高峰血糖及血糖曲线下面积(AUC) 等,同时观察餐后12 h平均血糖、血糖变异系数(CV)、平均血糖波动幅度(MAGE)。观察受试者是否出现夜间低血糖。结果 晚餐后0.5 h 运动组与晚餐后1 h 运动组,在餐后2 h 平均血糖、高峰血糖及血糖AUC方面均无统计学差异。但晚餐后1 h 运 动组餐后2 h即时血糖明显低于晚餐后0.5 h运动组(P=0.04)。同样,两组间餐后12 h平均血糖、CV及MAGE均无统计学差异, 且均无夜间低血糖发生。结论晚餐后0.5 h与晚餐后1 h进行短时中等强度运动对T2DM患者血糖谱影响无明显差异,均安全 有效。晚餐后1 h运动可能对降低餐后2 h血糖更有利,但对于易出现低血糖的患者餐后0.5 h运动可能更安全。
Abstract:
Objective To compare the effectiveness of moderate exercise for 30 min at 30 min and 60 min after dinner on glycemic control in patients with type 2 diabetes. Methods This randomized, crossover, self-controlled pilot study was conducted in 15 inactive patients with type 2 diabetes without serious complications or use of exogenous insulin. The participants completed two randomly ordered exercise protocols (brisk walking for 30 min at 30 min or 60 min after dinner on the exercise day) spaced 1 week apart. All the exercise was performed while maintaining a heart rate reserve of 40%. The interstitial glucose level was monitored using a continuous glucose monitor (CGM) for all the participants, who maintained a standardized diet with routine medications. The 2-h postprandial mean glucose, peak glucose, and glucose area under the curve (AUC) were measured. The mean amplitude of glycemic excursions (MAGE) and other plasma glucose fluctuation parameters in 12 h after dinner, including the mean blood glucose (MBG) and the coefficient variation (CV) of glucose, were also calculated. The incidence of nocturnal hypoglycemia was recorded in all the participants. Results The participants had a mean age of 46±11 years with a mean BMI of 25.8±3.1 kg/m2 and a mean HbA1c of 7.7%. No significant differences were found between postprandial 30 min exercise group and postprandial 60 min exercise group in terms of 2-h postprandial mean glucose, peak glucose, glucose AUC, or in MBG, CV and MAGE during the 12-h period after dinner. No nocturnal hypoglycemia occurred in the participants after exercise at 30 or 60 min after dinner. However, significant reductions in the 2-h postprandial glucose levels were detected after exercise at 60 min after dinner as compared to exercise at 30 min. Conclusion The timing (30 min vs 60 min after dinner) of moderate exercises for 30 min does not produce significant difference in the improvement of postprandial hyperglycemia in type 2 diabetic patients, and both exercise protocols are safe without a potential risk of hypoglycemia. Nevertheless, exercise at 60 min after dinner can be more effective to lower 2-h postprandial glucose, while exercise at 30 min after dinner might be safer for patients with a high risk of hypoglycemia.

相似文献/References:

[1]付文金,郑磊,王前,等.2 型糖尿病患者尿液组织因子及其促凝血活性检测的意义[J].南方医科大学学报,2011,(05):878.
[2]郭煜,朱波,李晨钟,等.自发性2型糖尿病大鼠血浆低脂联素血症导致胰岛素抵抗[J].南方医科大学学报,2011,(06):1014.
[3]杜宏,邵加庆,顾萍,等.早期大黄酸干预对db/db小鼠胰岛功能的影响[J].南方医科大学学报,2011,(09):1526.
[4]谭凤明,程喜平,陈盛强,等.不同年龄Ⅱ型糖尿病患者中黑白头发mtDNA异质性研究[J].南方医科大学学报,2012,(01):85.
[5]张定康,俞守义,耿仁文,等.国内应用胰岛素泵治疗2型糖尿病疗效循证研究[J].南方医科大学学报,2006,(08):1211.
[6]贾贺堂,张素华,纪立农,等.北京市100个早发糖尿病家系MODY1基因突变的筛查[J].南方医科大学学报,2006,(09):1301.
 JIA He-tang,ZHANG Su-hua,JI Li-nong,et al.Molecular scanning of MODY1 gene mutations in pedigrees of early onset type 2 diabetes in Beijing[J].Journal of Southern Medical University,2006,(10):1301.
[7]薛耀明,罗仁,朱波,等.六味地黄丸对自发性2型糖尿病大鼠内脏脂肪分布的影响[J].南方医科大学学报,2006,(10):1446.
 XUE Yao-ming,LUO Ren,ZHU Bo,et al.Liuweidihuang pills reduces visceral fat deposition in Otsuka Long-Evans Tokushima Fatty rats[J].Journal of Southern Medical University,2006,(10):1446.
[8]许小津,惠宏襄,蔡徳鸿.2型糖尿病患者与健康个体间肠道双歧杆菌的差异[J].南方医科大学学报,2012,(04):531.
[9]徐静,李楠,王俊红,等.2型糖尿病合并非酒精性脂肪肝大鼠肝脏SIRT1、UCP2 表达的变化[J].南方医科大学学报,2012,(05):726.
[10]李卫平,黎文,杨桃.同型半胱氨酸血症与2型糖尿病慢性并发症的关系[J].南方医科大学学报,2005,(03):349.
 LI Wei-ping,LI Wen,YANG Tao.Relationship between plasma homocysteine and chronic complications in type 2 diabetes mellitus[J].Journal of Southern Medical University,2005,(10):349.

更新日期/Last Update: 1900-01-01