[1]邓玲,陈薪,叶德盛,等.冻融胚胎移植周期内膜转化前血清高雌二醇水平不影响妊娠结局[J].南方医科大学学报,2018,(05):601.
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冻融胚胎移植周期内膜转化前血清高雌二醇水平不影响妊娠结局()
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《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2018年05期
页码:
601
栏目:
出版日期:
2018-05-15

文章信息/Info

Title:
Effect of serum estradiol level before progesterone administration on pregnancy outcomes of frozen-thawed embryo transfer cycles
作者:
邓玲陈薪叶德盛陈士岭
关键词:
冻融胚胎移植血清雌二醇妊娠结局
Keywords:
frozen thawed embryo transfer serum estradiol pregnancy outcome
摘要:
目的探讨冻融胚胎移植(FET)周期血清高雌二醇(E2)水平是否对妊娠结局有负面影响。方法回顾性分析2017年2月~8 月于本中心行激素替代治疗(HRT)-FET的205 个周期,根据内膜转化前E2水平分为高E2组(E2>600 pg/mL,45 例)和对照组 (E2≤600 pg/mL,160例)。比较两组的基本特征和妊娠结局。结果两组在对应取卵周期时的年龄、BMI、FET日内膜厚度等方 面的差异无统计学意义(P>0.05)。高E2组FET时的年龄小于对照组、雌激素使用天数大于对照组,且差异均具统计学意义(P< 0.05)。两组的临床妊娠率、继续妊娠率、早期流产率、晚期流产率及活产率之间的差异无统计学意义(P>0.05),且在控制FET 时的年龄和雌激素使用天数等混杂因素后,两组间妊娠结局的差异亦无统计学意义。结论HRT-FET周期内膜转化前血清高E2 水平不影响妊娠结局。
Abstract:
Objective To explore whether a high serum estradiol (E2) level before progesterone administration adversely affects the pregnancy outcomes of frozen-thawed embryo transfer (FET) cycles. Methods We retrospectively analyzed 205 hormone replacement therapy (HRT)-FET cycles in our Center between February, 2017 and August, 2017. With a cutoff value of serum E2 level of 600 pg/mL before progesterone administration, the cases were divided into high E2 level group and control group with normal E2 level, and the clinical characteristics and pregnancy outcomes were compared between the two groups. Results No significant difference was found between the two groups in the patients’age during IVF/ICSI cycle, body mass index (BMI) or endometrial thickness at the time of FET (P>0.05). The patients with high E2 levels had a significantly younger age (P<0.05) and a significantly longer duration of estradiol administration than those in the control group (P<0.05). The clinical pregnancy rates, ongoing pregnancy rates, early miscarriage rates, late abortion rates and live birth rates were all comparable between the two groups (P>0.05). After controlling for the compounding factors including the age at FET cycle and the duration of estradiol administration, all these pregnancy outcomes were still comparable between the two groups. Conclusion A high serum E2 level before progesterone administration does not adversely affect the pregnancy outcomes of HRT-FET cycles.

相似文献/References:

[1]郭薇,陈薪,叶德盛,等.口服地屈孕酮对冻融胚胎移植周期临床妊娠结局的影响[J].南方医科大学学报,2013,(06):861.

更新日期/Last Update: 1900-01-01