[1]严瑞明,陈晓静,王薇,等.肿瘤相关巨噬细胞与高危型人乳头状瘤病毒感染宫颈癌的临床相关性[J].南方医科大学学报,2018,(01):101.
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肿瘤相关巨噬细胞与高危型人乳头状瘤病毒感染宫颈癌的临床相关性()
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《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2018年01期
页码:
101
栏目:
出版日期:
2018-01-20

文章信息/Info

Title:
Correlation between tumor-associated macrophages and high-risk human papillomavirus infection in cervical cancer
作者:
严瑞明陈晓静王薇梁莉周琛斐魏文斐易红艳吴湘光刘国炳钟梅余艳红
关键词:
宫颈鳞状细胞癌高危型人乳头状瘤病毒肿瘤相关巨噬细胞CD163
Keywords:
squamous cervical cancer high-risk human papilloma virus tumor-associated macrophages CD163
摘要:
目的探讨肿瘤相关巨噬细胞与高危型人乳头状瘤病毒(hr-HPV)相关宫颈癌的发生发展的相关性。方法收集112例宫 颈组织临床样本,包含16例正常宫颈组织,55例宫颈上皮内瘤变和41例宫颈鳞状细胞癌,运用免疫组织化学法检测宫颈组织切 片中的CD163+巨噬细胞的表达水平,并对免疫组织化学法检测结果与临床数据进行统计学分析。结果免疫组化结果显示: CD163+巨噬细胞的细胞密度随着宫颈组织恶性变的程度增加而增多,且相关性分析示两者呈正相关(P=0.000)。同时,CD163+ 巨噬细胞的细胞密度在hr-HPV型宫颈癌中明显上调(P<0.05)。临床资料统计结果发现:CD163+巨噬细胞与宫颈癌的淋巴结转 移和FIGO分期有显著相关性(P=0.005,P=0.004)。结论CD163+巨噬细胞的表达与宫颈组织恶性变的程度成正相关,hr-HPV 感染与巨噬细胞中CD163的表达水平有显著相关性。CD163+巨噬细胞可作为hr-HPV感染所致宫颈癌发生发展的前瞻性预测 因素。
Abstract:
Objective To investigate the correlation between tumor-associated macrophages (TAMs) and the development of high risk human papilloma virus (hr-HPV)-related cervical cancer. Methods A total of 112 cases of cervical tissue were collected, including 16 normal cervical tissues, 55 cervical intraepithelial neoplasia (CIN) tissues and 41 squamous cervical cancer (SCC) tissues. The expression of CD163 + macrophages in the cervical tissues was detected by immunohistochemical method, and the results were analyzed in relation with the clinical data of the patients. Results Immunohistochemical analysis showed that the cell density of CD163+ macrophages increased progressively with the increase in the tissue malignancy, in the order of normal cervical tissue, CIN I, CIN II-III, and SCC. Correlation analysis revealed a positive relationship between CD163 + macrophage density and tissue malignancy (P=0.000). The density of CD163 + macrophages was significantly upregulated in HR-HPV-positive SCC tissue (P<0.05). CD163 + macrophages were positively correlated with cervical lymph node metastasis (P=0.005) and FIGO stage (P=0.004) of SCC. Conclusion The expression of CD163+ macrophages is positively correlated with malignant transformation of cervical tissues, and hr-HPV infection is significantly correlated with CD163 expression level in the macrophages. CD163 + macrophages can be used as predictors of the occurrence and progression of cervical cancer caused by hr-HPV infection.
更新日期/Last Update: 1900-01-01