[1]戴颖仪,黄志新,刘新通,等.影响大动脉粥样硬化性脑梗死复发的危险因素[J].南方医科大学学报,2017,(12):1678.
点击复制

影响大动脉粥样硬化性脑梗死复发的危险因素()
分享到:

《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2017年12期
页码:
1678
栏目:
出版日期:
2017-12-20

文章信息/Info

Title:
Risk factors for recurrence of large atherosclerotic cerebral infarction
作者:
戴颖仪黄志新刘新通王启章
关键词:
脑梗死卒中复发危险因素
Keywords:
cerebral infarction recurrent stroke risk factor
摘要:
目的研究首发大动脉粥样硬化性脑梗死患者复发的危险因素。方法连续入组在神经内科就诊的首发缺血性卒中患者, 并经CTA或MRA证实为大动脉粥样硬化性脑梗死。所有入组患者进行1年随访,根据随访期间是否复发脑梗死分为缺血性卒 中复发组和非复发组,比较两组患者的临床资料,并通过单因素方差分析、Cox回归模型确定复发性缺血性卒中的独立预测因 素。结果256例符合纳入标准,全部病例完成随访,30例(11.7%)随访期间发生缺血性脑血管事件。单因素方差分析显示,复 发组与非复发组在饮酒习惯(P=0.028)、吸烟(P=0.007)、高密度脂蛋白胆固醇(P=0.045)、缺血性心脏病(P=0.002)、抗高血压药 物(P=0.036)和他汀类药物(P=0.016)使用方面的差异有统计学意义。Cox回归分析显示不规则使用他汀类药物(HR=0.410, P=0.043)、吸烟(HR=2.253,P=0.043)、高密度脂蛋白胆固醇(HR=0.327,P=0.029)、缺血性心脏病(HR=8.566,P<0.001)与缺血 性脑卒中复发相关。结论不规则使用他汀类药物、低高密度脂蛋白水平、吸烟和既往有冠心病患者缺血性卒中复发风险较高。
Abstract:
Objective To explore the risk factors for recurrence of large atherosclerotic cerebral infarction in first-episode patients. Methods The consecutive patients with acute cerebral infarction diagnosed in the Department of Neurology were screened for large atherosclerotic cerebral infarction by CTA/MRA examination, and all the confirmed patients were followed up for 1 year. The patients were divided into recurrent ischemic stroke group and non-recurrent group according to occurrence of cerebrovascular events during the follow-up. Results A total of 256 eligible patients were included in this study, and all of them completed the follow-up. During the 1-year follow-up, 30 (11.7%) patients had ischemic cerebrovascular stroke events. Univariate analysis showed significant differences in alcohol drinking (P=0.028), smoking (P=0.007), high-density lipoprotein cholesterol (HDL; P=0.045), ischemic heart disease (P=0.002), antihypertensive agents (P=0.036) and statin use (P=0.016) between the recurrent group and non-recurrent group. Cox regression analysis showed that irregular use of statins (RR=0.410, P=0.043), smoking (RR=2.253, P=0.043), HDL (RR=0.327, P=0.029), and ischemic heart disease (RR=8.566, P<0.001) were correlated with recurrent ischemic stroke. Conclusion The first-episode patients with irregular use of statins, low HDL levels, smoking and ischemic heart disease are at higher risks for having ischemic stroke recurrence.

相似文献/References:

[1]李湘民,李静,曾凤,等.ITGA9基因rs189897与rs2212020及其单体型分子标志影响脑梗死发生[J].南方医科大学学报,2011,(07):1142.
[2]冀雅彬,吴永明,姬仲,等.不同低温诱导方式对大鼠脑梗死急性期的治疗效果比较[J].南方医科大学学报,2012,(01):89.
[3]邵合队,彭玉平.成功抢救大面积脑梗死伴特高血糖等多种严重并发症1例报告[J].南方医科大学学报,2004,(03):281.
 Successful rescue of extensive cerebral infarction with severe hyperglycemia and other severe complications: report of one case[J].,2004,(12):281.
[4]高菊华,高小平,潘速跃.阿托伐他汀强化治疗可减少大脑中动脉支架置入后脑血管事件的发生[J].南方医科大学学报,2016,(03):356.

更新日期/Last Update: 1900-01-01