[1]郭远波,徐金东,纪雪霞,等.右美托咪定对行肺癌根治术的患者围手术期炎症及肺功能保护作用的影响[J].南方医科大学学报,2017,(12):1673.
点击复制

右美托咪定对行肺癌根治术的患者围手术期炎症及肺功能保护作用的影响()
分享到:

《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2017年12期
页码:
1673
栏目:
出版日期:
2017-12-20

文章信息/Info

Title:
Protective effect of dexmedetomidine against perioperative inflammation and on pulmonary function in patients undergoing radical resection of lung cancer
作者:
郭远波徐金东纪雪霞张建杏梁杰贤周国斌
关键词:
肺癌根治术右美托咪定炎症肺功能保护作用
Keywords:
radical resection of lung cancer dexmedetomidine inflammation pulmonary function
摘要:
目的探讨右美托咪定对行肺癌根治术的患者围手术期炎症及肺功能保护作用的影响。方法选取我院2014年5月~2016 年5月的124例肺癌根治术患者进行研究,随机分为试验组和对照组各62例,对照组采用单一药物麻醉,试验组在对照组的基 础上进行右美托咪定麻醉,比较手术开始前(T0)、单肺通气(OLV)30 min(T1)、OLV 60 min(T2)及手术结束(T3)2组患者的血清 中IL-1β、IL-10 以及肿瘤坏死因子(TNF)-α水平变化,采用酶联免疫法(ELISA)测定两组术中肺脏组织标本匀浆中丙二醛 (MDA)、髓过氧化物酶(MPO)以及黄嘌呤氧化酶(XOD)水平,观察2 组的动脉血氧分压(PaO2)、氧合指数(OI)、气道平台压 (APP)和气道阻力(AR)。结果2组患者在T1和T2时间点IL-1β、IL-10、TNF-α、MDA、MPO、XOD均明显升高,而且试验组的IL- 1β、IL-10、TNF-α、MDA水平明显低于对照组,MPO、XOD明显高于对照组,差异具有统计学意义(P<0.05);2组患者在T1和T2点 的PaO2、OI明显降低,气道平台压和气道阻力明显升高,但是试验组气道平台压和气道阻力明显低于对照组,PaO2和OI明显高 于对照组,差异具有统计学意义(P<0.05)。结论肺癌根治术麻醉患者中采用右美托咪定麻醉可以有效的减轻肺部炎症反应, 并对患者的肺功起到重要保护作用。
Abstract:
Objective To study the protective effect of dexmedetomidine against perioperative inflammation and on pulmonary function in patients undergoing radical resection of lung cancer. Methods From May, 2014 to May, 2016, 124 patients with lung cancer receiving radical surgeries were randomized into experimental group (n=62) and control group (n=62). The patients in the control group received a single anesthetic agent for anesthesia, and additional dexmedetomidine was given in the experimental group. The levels of serum interleukin-1β (IL-1β), IL-10, and tumor necrosis factor-alpha (TNF-α) were measured before the operation (T0), at 30 min (T1) and 60 min (T2) during one lung ventilation (OLV) and at the end of operation (T3). Enzyme-linked immunosorbent assay (ELISA) was used to determine the levels of malondialdehyde (MDA), myeloperoxidase (MPO) and xanthine oxidase (XOD), and the arterial oxygen partial pressure (PaO2), oxygenation index (OI), airway plateau pressure (APP) and airway resistance (AR) were also recorded. Results At the time points of T1 and T2, IL-1β, IL-10, MDA, MPO, TNF-α, and XOD levels were significantly increased in both of the groups, but the levels of IL-1, IL-10, TNF-α and MDA were significantly lower and MPO and XOD levels significantly higher in the experimental group than in the control group (P< 0.05). In both groups, PaO2 and OI decreased and APP and AR increased significantly at T1 and T2, but APP and AR were significantly lower and PaO2 and OI significantly higher in the experimental group than in the control group (P<0.05). Conclusion Anesthesia with dexmedetomidine in lung cancer patients undergoing radical surgery can effectively reduce the inflammatory response of the lungs and protect the lung function of the patients.

相似文献/References:

[1]来勇,李雅兰,刘育勇,等.右美托咪定改善成人单肺通气时异丙酚-芬太尼平衡麻醉中的氧合功能[J].南方医科大学学报,2013,(07):1087.
[2]农丽丹,邓春玉,邝素娟,等.右美托咪定抑制五羟色胺诱导的人离体肺内小动脉收缩[J].南方医科大学学报,2014,(03):303.
[3]张奕文,邢祖民,徐颖华,等.不同剂量右美托咪定对老年患者腹腔镜下结直肠癌手术术后早期认知功能障碍的影响[J].南方医科大学学报,2014,(05):743.
[4]吉锦泉,王刚,孙柯,等.Narcotrend麻醉深度监测下右美托咪定复合丙泊酚在结肠息肉切除术中的应用[J].南方医科大学学报,2015,(02):264.
[5]梁芳果,欧阳铭文,王海棠.BIS反馈闭环路靶控输注右美托咪定可减少丙泊酚用量[J].南方医科大学学报,2015,(10):1497.
[6]斯妍娜,韩流,张媛,等.超声造影评价右美托咪定对兔肾缺血/再灌注损伤时微循环灌注的影响[J].南方医科大学学报,2016,(05):628.
[7]张卫东,张浩,汪海,等.右美托咪定对谷氨酸所致PC12细胞损伤的保护作用及其机制[J].南方医科大学学报,2017,(02):150.
[8]杨世辉,孙维国,李永乐,等.不同剂量右美托咪定复合罗哌卡因臂丛阻滞用于小儿多指手术的效果比较[J].南方医科大学学报,2017,(06):833.

更新日期/Last Update: 1900-01-01