[1]陈嘉伟,陈海斌,何强,等.宫颈癌放疗中基于精确表面剂量累加的直肠并发症预测模型[J].南方医科大学学报,2017,(12):1626.
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宫颈癌放疗中基于精确表面剂量累加的直肠并发症预测模型()
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《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2017年12期
页码:
1626
栏目:
出版日期:
2017-12-20

文章信息/Info

Title:
Rectal toxicity prediction based on accurate rectal surface dose summation for cervical cancer radiotherapy
作者:
陈嘉伟陈海斌何强廖煜良甄鑫
关键词:
宫颈癌放疗直肠并发症精确点配准剂量累加逻辑回归
Keywords:
cervical cancer rectum toxicity deformable registration dose accumulation logistic regression
摘要:
目的提出并验证一种应用于宫颈癌放疗的基于精确表面剂量累加的直肠并发症预测方法。方法回顾性采集到42例宫 颈癌患者数据,对各个治疗分次的直肠壁进行精确点配准得到变形场,利用该变形场对直肠壁受照剂量进行变形和叠加,得到 3D总剂量。将3D直肠总剂量分布映射到2D平面,分别提取出剂量体积特征和剂量几何特征,并筛选出有显著性差异(P< 0.05)的剂量分布特征,建立基于序列前向选择算法和逻辑回归的直肠并发症预测模型。结果直肠壁表面配准的精度较高,4 个相似度评价指标表明,配准后不同治疗分次的直肠表面配准程度有显著性提高。五折交叉验证结果显示准确性、敏感性、特 异性和AUC分别为:79.5%,81.3%,75.0%和0.88。结论本文提出基于精确表面剂量累加的直肠并发症预测模型具有可行性, 为宫颈癌患者直肠毒性预测提供可靠的支持。
Abstract:
Objective To propose arectal toxicity prediction method based on deformable surface dose accumulation. Methods The clinical data were collected retrospectively from 42patients receiving radiotherapy for cervical cancer. With the first fraction as the reference, the other fractions of rectum surface were registered to the reference fraction to obtain the deformation vector fields (DVFs), which were used to deform and sum the fractional rectal doses to yield the cumulative rectal dose. The cumulative rectal dose was flattened via 3D-2D mapping to generate a 2D rectum surface dose map. Two dosimetric features, namely DVPs and DGPs were extracted. Logistic regression embedded with sequential forward feature selection was used as the prediction model. The predictive performance was evaluated in terms of the accuracy, sensitivity, specificity, and the area under the receiver operating characteristic (ROC) curve (AUC). Results Significant improvements for rectum surface DIR were achieved. The best predictive results were achieved by using both DVPs and DGPs as the features with a sensitivity of 79.5%, a specificity of 81.3% and an AUC of 0.88. Conclusion The proposed method is feasible for predicting clinical rectal toxicity in patients undergoing radiotherapy for cervical cancer.
更新日期/Last Update: 1900-01-01