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MicroRNA-155在甲状腺乳头状癌中的表达及临床意义()

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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

Title:: Expression of microRNA-155 in papillary thyroid carcinoma and its clinical significance

摘要:: 目的探讨microRNA-155（miR-155）在甲状腺乳头状癌（papillary thyroid cancer, PTC）患者中的表达情况及与临床病理特征的相关性，miR-155指导PTC预后的可行性。方法收集86例PTC患者的癌及癌旁新鲜组织，用荧光定量PCR的方法检测 miR-155在上述组织中的表达，并结合其临床病理特点进行回顾性分析。结果69.8%（60/86）的PTC患者癌组织的miR-155表达较癌旁正常组织上调，相对上调倍数为2.63±2.73倍；而在表达上调组中，PTC原发灶更大［（1.66±0.96）cm vs（1.19±0.52）cm， P=0.021］；更容易出现甲状腺包膜外侵犯（56.7% vs 23.1%，P=0.004）；淋巴结转移率更高（70% vs 46.2%，P=0.036）；具有更晚的 TNM分期，Ⅲ~Ⅳ期的比例更高（20% vs 0%，P=0.014）。PTC癌组织中miR-155相对表达量（ΔCT）高低与淋巴结转移个数具备一定的相关性（r=0.531，P=0.001）。结论PTC中miR-155的高表达具有更大肿瘤病灶，更易甲状腺包膜外侵犯，更高颈部淋巴结转移率及更晚的TNM分期等临床病理特点，可能作为不良临床预后的判断指标之一。

Abstract:: Objective To investigate the correlation of microRNA-155 (miR-155) expression with clinicopathological features of patients with papillary thyroid carcinoma (PTC) and explore the value of miR-155 in prognostic assessment of PTC. Methods We collected 86 pairs of fresh PTC and adjacent tissues to examine the expression of miR-155 using fluorescent quantitative PCR. miR-155 expressions in the tissues were analyzed in relation to the clinicopathological features of the patients. Results Compared with the paired adjacent tissues, 69.8% (60/86) of the PTC tissues showed up-regulated miR-155 expression by 2.63± 2.73 folds. Up-regulated miR-155 expressions were associated with a larger tumor size (1.66±0.96 vs 1.19±0.52 cm, P=0.021), a higher likeliness of extrathyroid invasion (56.7% vs 23.1%, P=0.004), a higher rate of lymph node metastasis (70% vs 46.2%, P= 0.036), a more advanced TNM stage, and a higher rate of III-IV stage of the tumor (20% vs 0%, P=0.014). The expression level of miR-155 in PTC tissues was positively correlated with lymph node metastasis (r=0.531, P=0.001). Conclusion PTC patients with miR-155 over-expression tend to have a greater tumor size, a greater likeliness of extrathyroid involvement, a higher rate of cervical lymph node metastasis and a more advanced TNM stage. The high expression of miR-155 in the tumor may indicate a poor prognosis of PTC patients.

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更新日期/Last Update: 1900-01-01