[1]李晶,潘群皖,朱再满,等.吗啡依赖大鼠觅药消退期边缘下区遥测脑电活动的变化[J].南方医科大学学报,2015,(05):733.
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吗啡依赖大鼠觅药消退期边缘下区遥测脑电活动的变化()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2015年05期
页码:
733
栏目:
出版日期:
2015-05-15

文章信息/Info

Title:
Changes of telemetry electrical activity in the infralimbic cortex of morphine-dependent
rats with extinguished drug-seeking behavior
作者:
李晶潘群皖朱再满李敏白羽虞冉
关键词:
吗啡依赖觅药消退边缘下区遥测脑电活动
Keywords:
morphine dependence drug-seeking extinction infralimbic cortex telemetry brain electrical activity
摘要:
目的探讨吗啡依赖大鼠觅药消退期边缘下区(infralimbic cortex, IL)遥测脑电活动的变化对觅药行为的影响及其机制。
方法将SD大鼠随机分成模型组和对照组,在IL区实施脑立体定位电极埋植,模型组大鼠依次制成吗啡依赖和消退模型,应用
无线遥测系统记录大鼠消退期IL区脑电活动的变化。结果模型组大鼠戒断1~2 d白箱停留时间明显长于吗啡注射前及对照
组;消退训练后1~2 d,模型组大鼠白箱停留时间比戒断期明显缩短,与吗啡注射前及对照组相比,无明显差异。模型组与对照
组比较,戒断2 d停留白箱时,IL区脑电β波显著增多,δ波显著减少;从黑箱向白箱穿梭时,δ波显著增多,α波和β波显著减少。消
退2 d,模型组大鼠停留白箱时,IL区脑电比对照组θ波明显减少,与戒断期比较β波和θ波明显减少,δ波明显增多;从黑箱向白箱
穿梭时,与对照组相比IL脑电无显著差异,但与戒断期比较,δ波明显减少,α波和β波明显增多。结论吗啡依赖大鼠觅药消退期
IL区脑电活动发生异常变化,这种异常脑电的产生可能影响觅药动机的形成,进而抑制觅药行为的表达和维持。
Abstract:
Objective To investigate the changes of telemetry electrical activity in the infralimbic cortex (IL) of morphinedependent
rats with extinguished drug-seeking behavior. Methods SD rats were randomly divided into model group and
control group and received operations of brain stereotaxic electrode embedding in the IL. The rats in the model group were
induced to acquire morphine dependence and then received subsequent extinction training, and the changes of electrical
activity in the IL were recorded with a physical wireless telemetry system. Results In rats with morphine dependence, the time
staying in the white box was significantly longer on days 1 and 2 after withdrawal than that before morphine injection and that
of the control rats, but was obviously reduced on days 1 and 2 after extinction training to the control level. Compared with the
control group, the morphine-dependent rats on day 2 following withdrawal showed significantly increased β wave and
decreased δ wave when they stayed in the white box but significantly increased δ wave and decreased α wave and β wave
when they shuttled from the black to the white box. On day 2 of extinction, the model rats, when staying in the white box,
showed significantly decreased θ wave compared with that of the control rats group but decreased β wave and θ wave and
increased δ wave compared with those in the withdrawal period. When they shuttled from black to white box, the model rats
showed decreased δ wave and increased α wave and β wave compared with those in the withdrawal period. Conclusion
Morphine-dependent rats have abnormal changes of electrical activity in the IL in drug-seeking extinction to affect their
drug-seeking motive and inhibit the expression and maintenance of drug-seeking behaviors.

相似文献/References:

[1]莫志贤,梁荣能,翁建霖.吗啡长时程作用对新生鼠TM神经细胞cAMP和cGMP的影响以及青藤碱的干预作用[J].南方医科大学学报,2005,(09):1105.
 MO Zhi-xian,LEUNG Wing-nang,YUNG Kin-lam.Changes in cAMP and cGMP levels in neonatal rat histaminergic neurons of tuberomammillary nucleus following 48-hour morphine exposure and effects of sinomenine intervention[J].Journal of Southern Medical University,2005,(05):1105.

更新日期/Last Update: 1900-01-01