[1]林茴,陈小欢,吴志华,等.糖尿病患者脑钠肽前体水平与心率变异性的相关性[J].南方医科大学学报,2015,(01):146.
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糖尿病患者脑钠肽前体水平与心率变异性的相关性()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2015年01期
页码:
146
栏目:
出版日期:
2015-01-15

文章信息/Info

Title:
Association of pro-B-type natriuretic peptide levels with heart rate variability in diabetic
patients
作者:
林茴陈小欢吴志华张东辉陈晓燕
关键词:
糖尿病心率变异性脑钠肽前体心脏自主神经病变
Keywords:
diabetes heart rate variability pro-B-type natriuretic peptide cardiac autonomic neuropathy
摘要:
目的探讨糖尿病患者脑钠肽前体水平(NT-proBNP)和心率变异性(HRV)的相关性。方法对58 例糖尿病患者均进行
HRV分析与NT-proBNP测定,按HRV结果分为HRV异常组和HRV正常组,比较两组的时域和频域指标以及NT-proBNP水平,
并将所有患者的HRV指标与NT-proBNP进行相关性分析。结果HRV异常组NT-proBNP水平(320.2±88.3 pg/ml)与HRV正
常组(80.4±25.2 pg/ml)比较,显著增高(P<0.01),NT-proBNP 与SDNN、三角指数、低频功率、极低频功率负相关(r=-0.55, P<
0.05; r=-0.52, P<0.05; r=-0.62, P<0.01; r=-0.56,P<0.05)。结论糖尿病患者NT-proBNP 水平与HRV相关,NT-proBNP 升高提
示糖尿病的心脏自主神经病变。
Abstract:
Objective To investigate the correlation between pro-B-type natriuretic peptide (NT-proBNP) and heart rate
variability (HRV) in patients with diabetes. Methods HRV and NT-proBNP levels were assessed in 58 patients with diabetes.
The time domain and frequency domain indices and the level of NT-proBNP were compared between patients with normal
and abnormal HRV, and the correlation of HRV index and NT-proBNP was analyzed. Results The NT-proBNP level was
significantly higher in patients with abnormal HRV than in those with normal HRV (320.2±88.3 vs 80.4±25.2 pg/ml, P<0.01).
The level of NT-proBNP was negatively correlated with SDNN (r=-0.55, P<0.05), triangle index (r=-0.52, P<0.05), LF (r=-0.62, P<
0.01), and VLF (r=-0.56, P<0.05). Conclusion NT-proBNP level is correlated with HRV, and an increased NT-proBNP indicates
cardiac autonomic neuropathy in diabetic patients.

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更新日期/Last Update: 1900-01-01