[1]闵卫利,代志军,张寅斌,等.磷酸化caspase-8 在非小细胞肺癌中的表达及其临床意义[J].南方医科大学学报,2014,(12):1753.
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磷酸化caspase-8 在非小细胞肺癌中的表达及其临床意义()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2014年12期
页码:
1753
栏目:
出版日期:
2014-12-20

文章信息/Info

Title:
Expression of phosphorylated caspase-8 in non-small cell lung cancer and the clinical
implications
作者:
闵卫利代志军张寅斌王西京赵阳
关键词:
Src激酶caspase-8磷酸化非小细胞肺癌
Keywords:
Src caspase-8 phosphorylation non-small cell lung cancer
摘要:
目的探索Src对caspase-8的磷酸化作用对非小细胞肺癌患者的临床意义。方法应用免疫组化方法检测Src及caspase-8
在非小细胞肺癌组织及对照肺组织中的表达,应用Western blot 检测非小细胞肺癌组织和对照肺组织的磷酸化caspase-8
(p-Y380-casp8)的表达,Kaplan-Meire法分析p-Y380-casp8阳性组和阴性组的无疾病生存情况。结果Caspase-8与Src在非小
细胞肺癌组织和对照肺组织中阳性表达率无显著性差异(P>0.05),免疫组化caspase-8(+)Src(+)的非小细胞肺癌组织中磷酸化
caspase-8均阳性表达,磷酸化caspase-8在非小细胞肺癌组织中的阳性率显著高于对照肺组织(52.4% vs 7.1%,P<0.05),磷酸化
caspase-8阳性表达非小细胞肺癌患者组术后2年无疾病生存率显著低于磷酸化caspase-8阴性组(32.0% vs 60.3%,P<0.05)。结
论磷酸化caspase-8 可以成为非小细胞肺癌患者不佳预后的标志分子,为临床非小细胞肺癌患者预后评估提供了全新理论
基础。
Abstract:
Objective To investigate the clinical significance of phosphorylated caspase-8 by Src in patients with operable
non-small cell lung cancer. Methods Src and caspase-8 expressions were tested using immunohistochemistry in non-small cell
lung cancer tissues and control lung tissues. The expression of phosphorylated caspase-8 at 380 tyrosine by Src was detected
using Western blotting. The disease-free survival (DFS) of patients positive and negative for phosphorylated caspase-8 was
analyzed with Kaplan-Meire survival curve. Results No significant difference was found in the positivity rate of caspase-8 or
Src between the cancer tissues and control lung tissues (76.3% vs 83.3%, P>0.05; 70.1% vs 66.4%, P>0.05). All the patients with
Casp8- and Src-positive cancers were positive for phosphoryalted caspase-8, whose expression rate was significantly higher in
the cancer tissues than in the paired control lung tissues (52.4% vs 7.1%, P<0.05). The 2-year DFS was significantly higher in
patients negative for phosphorylated caspase-8 than in the positive patients (32.0% vs 60.3% , P<0.05). Conclusion
Phosphorylated caspase-8 may serve as a predictor for a poorer DFS in patients with operable non-small cell lung cancer.

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更新日期/Last Update: 1900-01-01