[1]司彤,刘春晓,许凯,等.miR-199a在肾细胞癌中的表达与临床病理特征及预后的关系[J].南方医科大学学报,2012,(11):1568.
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miR-199a在肾细胞癌中的表达与临床病理特征及预后的关系()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2012年11期
页码:
1568
栏目:
出版日期:
2012-11-15

文章信息/Info

Title:
Association of miR-199a expression with clinicopathologic characteristics and prognosis of renal cell carcinoma
作者:
司彤刘春晓许凯桂耀庭
关键词:
肾细胞癌miR-199a预后
Keywords:
renal cell carcinoma miR-199a prognosis
摘要:
目的检测miR-199a在肾细胞癌及癌旁相对正常肾组织中的表达量,分析其相对表达量和肾细胞癌相关的临床病理特征
及其对肾细胞癌预后判断的意义。方法采用RT-qPCR检测67例肾细胞癌及癌旁正常组织miR-199a表达,分析表达的差异与
临床病理特征间的关系。结果在肾细胞癌和癌旁相对组织中均有不同程度的表达,在肾细胞癌的表达显著低于癌旁相对正常
组织,均值13.7倍(P=0.003)。miR-199a的表达在不同肿瘤浸润程度及复发程度之间存在差别(P<0.05,χ2=4.215),
而与年龄、组织学类型、淋巴结转移、远处转移、Fuhrman分级等无统计学关联(P>0.05)。miR-199a下调组生存期明显低于对照组(Log-rank
test,P=0.017)。结论miR-199a表达下调与肾癌患者原发肿瘤浸润程度、复发及预后不良有关,可作为评估肾癌预后有价值的
一种指标。
Abstract:
ObjectiveTo investigate the association of miR-199a expression with the clinicopathologic characteristics and the
survival of patients with renal cell carcinoma (RCC). MethodsReal-time quantitative RT-PCR was used to detect the
expression of miR-199a in the tumor tissues and paired adjacent normal tissues from67patients with RCC. The correlations of
miR-199a expression with the clinicopathologic characteristics and survival of RCC patients were analyzed.ResultsPositive
miR-199a expression was detected in both the RCC and adjacent normal tissues, but the tumor tissues showed a significantly
lower expression level by a mean of 13.7folds (P=0.003). The expression of miR-199a was negatively correlated with tumor
recurrence in RCC patients in T stage (P<0.05), but showed no significant correlations with the patients’age, histological type
of the tumor, lymph node metastasis, distal metastasis, or Fuhrman grade (P>0.05). The patients with lowered miR-199a
expression in the tumor tissue had a significantly shorter mean survival time than those without miR-199a down-regulation (P=
0.017by Log-rank test).ConclusionA decreased expression of miR-199a is significantly correlated with a higher tumor stage, a
greater likeliness of tumor recurrence, and a poorer prognosis in RCC patients. miR-199a can serve as a promising prognostic
factor of renal cell carcinoma.

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更新日期/Last Update: 1900-01-01