[1]梁仕伟,陈晔明.长托宁或阿托品与新斯的明合用拮抗肌肉松驰药残余作用时对血流动力学影响的比较[J].南方医科大学学报,2005,(12):1581-1582.
 LIANG Shi-wei,CHEN Ye-ming.Effects of penehyclidine hydrochloride or atropine combined with neostigmine for antagonizing residual neuromuscular block on patient’s hemodynamics[J].,2005,(12):1581-1582.
点击复制

长托宁或阿托品与新斯的明合用拮抗肌肉松驰药残余作用时对血流动力学影响的比较()
分享到:

《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2005年12期
页码:
1581-1582
栏目:
出版日期:
2005-12-01

文章信息/Info

Title:
Effects of penehyclidine hydrochloride or atropine combined with neostigmine for antagonizing residual neuromuscular block on patient’s hemodynamics
作者:
梁仕伟 陈晔明
南方医科大学南方医院麻醉科, 广东, 广州, 510515
Author(s):
LIANG Shi-wei CHEN Ye-ming
Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
关键词:
长托宁阿托品新斯的明神经肌肉阻滞血流动力学
Keywords:
penehyclidine hydrochlorideatropineneostigmineneuromuscular blockhemodynamics
分类号:
R614.22;R971.2
摘要:
目的 观察长托宁或阿托品与新斯的明合用拮抗肌肉松驰其他药残余作用时对血流动力学的影响。方法 择期上腹部手术成年病人80例,随机分为长托宁组和阿托品组,每组各40例。手术结束后5min,静脉注射新斯的明0.03mg/kg·b.w.、长托宁0.02mg/kg·b.w.或阿托品0.02mg/kg·b.w.拮抗残余的肌肉松驰其他作用。记录全麻诱导前5min、给药前1min及给药后2、5、10、15min各时点的心率、血压、呼气末二氧化碳分压(PETCO2)的变化。结果 长托宁组给药前后的心率变化不大(P>0.05);阿托品组给药后心率显著增加(P<0.01),给药后15min时仍未恢复到给药前水平。在整个观察期间,两组血压和PETCO2无显著变化(P>0.05),组间比较也无显著性差异(P>0.05)。结论 与阿托品比较,长托宁对心率、血压均无明显影响,而阿托品却使心率显著增快。
Abstract:
Objective To investigate the effects of penehyclidine hydrochloride(PH)/atropine combined with neostigmine for antagonizing residual neuromuscular block on the hemodynamics. Methods Eighty patients with elective upper abdominal surgery were randomized equally into PH group and atropine group. Five minutes after the completion of surgery, PH 0.02 mg/kg (in PH group) or atropine 0.02 mg/kg (in atropine group) in combination with neostigime 0.03 mg/kg were given intravenously to reverse the residual neuromuscular block. The heart rate (HR), mean arterial pressure (MAP) and end-tidal CO2 pressure (PETCO2 ) were recorded 5 min before anesthesia induction, 1 min before injection and 2, 5, 10, and 15 min after injection, respectively. Results During the investigation, HR in PH group did not undergo conspicuous changes (P>0.05). HR after the injection was markedly faster than that before the injection in atropine group (P<0.01) and did not recover till 15 min after the injection (P>0.05). MAP and PETCO2 showed no evident changes and no significant difference was observed between the two groups during the investigation (P>0.05). Conclusion Compared with atropine, PH does not obviously affect HR and BP, but atropine may accelerate HR.

参考文献/References:

[1] 曾繁忠.新药长托宁研究和应用概况论文集[C].成都:四川科技出版社,2002.4-14.
[2] 杭燕南,庄心良,蒋豪,等.当代麻醉学[M].上海科学技术出版社,2002.346-54.
[3] 刘俊杰,赵俊.现代麻醉学[M].北京:人民卫生出版社,2004.586-8.
[4] Marine JE,Watanabe MA,Smith TW,et al.Effect of atropine on heart rate turbulence[J].Am J Cardiol,2002,89(6):767-9.
[5] 高东艳,陈丽,白玲.长托宁与东莨菪碱在心脏病人非心脏术中的应用[J].临床麻醉学杂志,2005,21(2):126-7.
[6] Han XY,Liu H,Liu CH,et al.Synthesis of the optical isomers of a new anticholinergic drug,penehyclidine hydrochloride [J].Bioorg Med Chem Lett,2005,15(8):1979-82.
[7] 韩继媛,曹锋生,王一镗,等.长托宁的临床应用[J].中华急诊医学杂志,2005,14(2):173-4.

备注/Memo

备注/Memo:
收稿日期:2005-4-25。
作者简介:梁仕伟(1963- ),男,硕士,副教授、副主任医师,电话:020-61642350.
更新日期/Last Update: 1900-01-01