[1]陈利锋,柯以铨,杨志林,等.光动力学疗法与间质内化疗联合治疗脑胶质瘤的临床研究[J].南方医科大学学报,2005,(01):116-118.
 CHEN Li-feng,KE Yi-quan,YANG Zhi-lin,et al.Effect of photodynamic therapy combined with interstitial chemotherapy for gliomas[J].Journal of Southern Medical University,2005,(01):116-118.
点击复制

光动力学疗法与间质内化疗联合治疗脑胶质瘤的临床研究()
分享到:

《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2005年01期
页码:
116-118
栏目:
出版日期:
2005-01-01

文章信息/Info

Title:
Effect of photodynamic therapy combined with interstitial chemotherapy for gliomas
作者:
陈利锋 柯以铨 杨志林 王松青 徐如祥
南方医科大学珠江医院神经外科, 广东广州510282
Author(s):
CHEN Li-feng KE Yi-quan YANG Zhi-lin WANG Song-qing XU Ru-xiang
Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
关键词:
脑肿瘤神经胶质瘤光动力学疗法间质内化疗
Keywords:
brain neoplasmsgliomaphotodynamic therapyinterstitial chemotherapy
分类号:
R739.41
摘要:
目的 探讨显微手术后联合光动力学疗法(PDT)与局部间质化疗对脑胶质瘤的疗效。方法 28例脑胶质瘤患者术中尽可能多地切除肿瘤后行PDT首次照射,并在残瘤腔内埋置Ommaya囊,24h后行PDT复照。通过Ommaya囊向瘤腔内注射卡氮介行局部间质化疗。随访2年。结果 1年复发2例(7.1%),1年生存25例(89.3%),2年生存17例(65.7%)。结论 显微手术后联合PDT与局部间质化疗治疗脑胶质瘤能有效抑制肿瘤生长,控制复发,延长生存期,改善生存质量,是一种安全有效的综合治疗脑胶质瘤的方法。
Abstract:
Objective To investigate the therapeutic effect of photodynamic therapy (PDT) combined with interstitial chemo-therapy on gliomas after microsurgery. Methods Twenty-eight patients with glioma received microsurgery for glioma resection as much as possible, during which PDT was carried out and an Ommaya bursa implanted into the cavity left by the resected tumor. PDT was performed again 24 h after the operation and carmustine injected into the Ommaya bursa for interstitial chemotherapy at the different time after the operation. The follow-up study lasted for 2 years. Results Two of the 28 patients had relapse of glioma within 1 year after the operation, with the 1-year survival rate of 89.3% (25/28) and 2-year survival rate of 65.7% (17/28). Conclusions PDT combined with interstitial chemotherapy following microsurgery provides a safe and effective treatment of glioma, which can inhibit glioma growth, decrease the recurrence rate, prolong the patients’ survival and improve their quality of live.

参考文献/References:

[1] 孙燕.内科肿瘤学[M].北京:人民卫生出版社,2001.497-501.
[2] Harbaugh KS, Black PM. Strategies in the surgical management of malignant gliomas[J]. Semin Surg Oncol, 1998, 14(1): 26-33.
[3] Gaspar LE, Zamorano LJ, Shamsa F, et al. Permanent 125iodine implants for recurrent malignant gliomas [J]. Radiat Oncol Biol Phys, 1999, 43(5): 977-82.
[4] Halligan JB, Stelzer KJ, Rostomily RC, et al. Operation and permanent low activity 125I brachytheraphy for recurrent high-grade astrocytomas[J]. Int J Radiat Oncol Biol Phys, 1996, 35(3): 541-7.
[5] Crossen JR, Garwood D, Glatstein E. Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy[J]. Clin Oncol, 1994, 12: 627-42.
[6] Burton EC, Prados MD. Malignant gliomas[J]. Curr Treat Options Oncol, 2000, 1(5): 459-68.
[7] Nieder C, Grosu AL, Molls M, et al. A comparison of treatment results for recurrent malignant gliomas [J]. Cancer Treat Rev, 2000,26(6): 397-409.
[8] Eljamel MS. New light on the brain: The role ofphotosensitizing agents and laser light in the management of invasive intracranial tumors[J]. Technol Cancer Res Treat, 2003, 2(4): 303-9.
[9] Gupta S, Dwarakanath BS, Muralidhar K, et al. Role of apoptosis in photodynamic sensitivity of human tumour cell lines [J]. Exp Biol,2003, 41(1): 33-40.
[10] Popovic EA, Kaye AH, Hill JS. Photodynamic therapy of brain tumors[J]. Clin Laser Med Surg, 1996, 14(5): 251-61.
[11] Goetz C, Hasan A, Stummer W. Experimental research photodynamic effects in perifocal, oedematous brain tissue[J]. Acta Neurochir (Wien), 2002, 144(2): 173-9.
[12] Muller PJ, Wilson BC. Photodynamic therapy for recurrent supratentorial glinmas[J]. Semin Surg Oncol, 1995, 11(5): 346-54.
[13] Mason JO, Fischer DH. Intrathecal chemotherapy for recurrent central nervous system intraocular lymphoma [J]. Ophthalmology, 2003,110(6): 1241-4.

相似文献/References:

[1]彭林,程江鹏,黄理金,等.颅内神经内分泌癌1例报告[J].南方医科大学学报,2005,(05):597.
[2]李申一,徐世元,叶小平,等.利多卡因对脑肿瘤患者麻醉诱导时脑氧供需平衡和血液动力学的影响[J].南方医科大学学报,2004,(02):223.
 LI Shen-yi,XU Shi-yuan,YE Xiao-ping,et al.Effects of lidocaine on cerebral oxygen supply-consumption balance and hemodynamics during anesthesia induction in patients with supratentorial tumor[J].Journal of Southern Medical University,2004,(01):223.

备注/Memo

备注/Memo:
收稿日期:2004-11-3。
作者简介:陈利锋(1976- ),男,在读硕士研究生,电话:020-61643263,E-mail:supertank@126.com
通讯作者:柯以铨(1963- ),男,博士,教授,主任医师,电话:020-61643266,E-mail:keyiquan@hotmail.com
更新日期/Last Update: 1900-01-01