[1]郭燕舞,徐如祥.持续性植物状态患者脑脊液中氨基酸类神经递质的检测[J].南方医科大学学报,2005,(01):71-74.
 GUO Yan-wu,XU Ru-xiang.Detection of amino acid neurotransmitters in cerebrospinal fluid of patients in persistent vege-tative state[J].Journal of Southern Medical University,2005,(01):71-74.
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持续性植物状态患者脑脊液中氨基酸类神经递质的检测()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2005年01期
页码:
71-74
栏目:
出版日期:
2005-01-01

文章信息/Info

Title:
Detection of amino acid neurotransmitters in cerebrospinal fluid of patients in persistent vege-tative state
作者:
郭燕舞 徐如祥
南方医科大学珠江医院神经医学研究所神经外科, 广东广州510282
Author(s):
GUO Yan-wu XU Ru-xiang
Department of Neurosurgery, Institute of Neuroscience, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
关键词:
高效液相色谱分析持续性植物状态脑脊液氨基酸神经递质
Keywords:
high-performance liquid chromatographypersistent vegetative statecerebrospinal fluidamino acidneurotransmitters
分类号:
R338;R446;R446.14
摘要:
目的 应用高效液相色谱分析法检测持续性植物状态(PVS)患者脑脊液中氨基酸类神经递质,观察其与临床表现的相关性。方法 分别采集46例PVS患者与20例对照病人的脑脊液,检测谷氨酸、天冬氨酸、丙氨酸、甘氨酸的含量。结果 4种氨基酸在25min内得以较好分离。PVS组4种递质水平均高于对照组,且递质水平与PVS评分呈负相关,其中甘氨酸及丙氨酸与对照组相比差异有统计学意义(P<0.05)。结论 PVS患者脑脊液中氨基酸类递质与临床表现有一定的相关性。
Abstract:
Objective To detect the amino acid neurotransmitters in cerebrospinal fluid of patients in persistent vegetative state (PVS) to define their relation to the clinical manifestations of the patients. Methods The cerebrospinal fluid from 46 patients in PVS and 20 control patients were collected for detection of glutamic acid, aspartic acid, alanine and glycine by high-performance liquid chromatography. Results All the four amino acids were separated by chromatography within 25 min. The contents of all the 4 neurotransmitters in PVS group were higher than those in the control group, and their contents were inversely correlated to PVS score of the patients. The differences in the concentration of glycine and alanine were significant between PVS patients and the control patients (P<0.05). Conclusion The patient’s clinical manifestations are related to the contents of amino acid neurotransmitters in the cerebrospinal fluid of PVS patients.

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备注/Memo

备注/Memo:
收稿日期:2004-5-17。
基金项目:军队十五重点课题(No.01z054)
作者简介:郭燕舞(1977- ),男,2000年毕业于第一军医大学,医学硕士,医师,助教,电话:020-88395615,E-mail:dguoyanwu@163.com
更新日期/Last Update: 1900-01-01