[1]姚华强,彭瑛,钟世镇,等.PDGFR及c-Fos的表达与膀胱癌临床生物学特征的关系[J].南方医科大学学报,2004,(02):177-179,183.
 YAO Hua-qiang,PENG Ying,ZHONG Zhi-zhen,et al.Association of the expressions of platelet-derived growth factor receptor and c-Fos with the biological characteristics of bladder cancer[J].Journal of Southern Medical University,2004,(02):177-179,183.
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PDGFR及c-Fos的表达与膀胱癌临床生物学特征的关系()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2004年02期
页码:
177-179,183
栏目:
出版日期:
2004-02-01

文章信息/Info

Title:
Association of the expressions of platelet-derived growth factor receptor and c-Fos with the biological characteristics of bladder cancer
作者:
姚华强1 彭瑛2 钟世镇1 何恢绪3 李忠华1
1. 第一军医大学临床解剖研究所, 广东, 广州, 510515;
2. 广州军区联勤部东皋干休所, 广东, 广州, 510055;
3. 广州军区总医院泌尿外科, 广东, 广州, 510010
Author(s):
YAO Hua-qiang1 PENG Ying2 ZHONG Zhi-zhen1 HE Hui-xu3 LI Zhong-hua1
1. Institute of Clinical Anatomy, First Military Medical University, Guangzhou 510515, China;
2. Donggao Sanatorium of Combined Service Force of Guangzhou Command, Guangzhou 510055, China;
3. Department of Urology, General Hospital of Guangzhou Command, Guangzhou 510010, China
关键词:
膀胱肿瘤血小板源性生长因子受体c-Fos蛋白
Keywords:
bladder carcinomaplatelet-derived growth factor receptorc-Fos protein
分类号:
R737.14
摘要:
目的 探讨膀胱移行上皮细胞癌(BTCC)组织中血小板源性生长因子受体(PDGFR)及癌蛋白c-Fos(c-Fos)的表达与BTCC的关系。方法 应用免疫组化SP法检测43例BTCC组织、11例正常膀胱组织、14例癌旁组织中PDGFR及c-Fos的表达。结果 PDGFR表达于胞膜、核膜和胞质;c-Fos表达于胞核和胞质。PDGFR和c-Fos在BTCC组织表达阳性率均显著高于正常和癌旁组织(P<0.05);两者在BTCC血管中的染色明显深于正常血管。c-Fos的表达在BTCC的分级中存在显著性差异(P<0.05)。结论 PDGFR和c-Fos的表达可调控膀胱的多种组织,过度表达与BTCC的发生密切相关,并可能与肿瘤的血管形成相关。c-Fos的表达可反映BTCC细胞的增殖状态。
Abstract:
Objective To elucidate the relation of platelet-derived growth factor receptor (PDGFR) and c-Fos protein expressions with human bladder transitional epithelial cell carcinoma (BTCC). Methods The expressions of PDGFR and c-Fos were investigated in 11 normal bladder tissue samples, 14 adjacent non-carcinoma tissues and 43 BTCC tissues by means of SP immunohistochemical technique. Results The c-Fos expression was found in the cell nuclei and cytoplasm, and PDGFR in the nuclear membrane, cytoplasm, and cellular membrane. PDGFR and c-Fos were detected in 81.40% and 48.83% of the BTCC tissues respectively, at the rates both significantly higher than those in normal and adjacent non-carcinoma tissues (P<0.05). Correlation between the expression of c-Fos and the tumor grading was noted (P<0.05). The expressions of PDGFR and c-Fos in tumor blood vessels were significantly higher than those in normal vessels. Conclusions The expressions of PDGFR and c-Fos might be involved in the development of BTCC, possibly related to the angiogenesis of the tumors. c-Fos expression can indicated the cell proliferative status of the BTCC.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2003-8-9。
基金项目:广东省科技计划项目(A302020401)
作者简介:姚华强(1966-),男,广西北海人,第一军医大学在读博士研究生,主治医师,E-mail:y99333@2911.net
更新日期/Last Update: 1900-01-01